Obesity – as already mentioned – is not only an aesthetic problem, since this disease is often associated with a variety of secondary diseases, especially cardiovascular ones; Therefore, correct dietary habits and lifestyle is necessary to take the most of a therapeutic strategy against obesity. Generally, the obese patient needs a team doctor consisting of nutritionists, dietitians and obesity experts, who point to a reduced-calorie, balanced diet. A loss equal to 5-10% of their weight must be considered already a great achievement for the obese patient: a similar weight reduction will allow the patient to improve his overall health picture.
To help the obese patient, drugs play a role so important, but secondary, and negligible in the absence of a diet and lifestyle.
The following are the classes of drugs used in most anti-obesity therapy, and some specialty drug samples; It is then up to the doctor to choose the principle more suitable for the patient, depending on the severity of the disease, the State of health of the patient and his response to care:
Sibutramine (es. Reductil, Reduxade, Ectiva, Meridia) like antidepressants, sibutramine acts by inhibiting the re uptake of serotonin, norepinephrine and dopamine, and promoting the feeling of satiety; Consequently, the patient suffering from obesity has less appetite. In addition, the drug stimulates basal metabolism, has a therapeutic effect thermogenic (norepinephrine inhibit the unleashes a likable). Indicatively, take this medicine at the dosage of 10 mg orally, once a day. From 1/24/2010, the drug has been banned from the market because of its side effects (increased blood pressure, increased heart rate, dry mouth, insomnia, headaches)
Glucobay, Glicobase: also used in the treatment of diabetes. Tentatively, it is recommended to take half a Tablet (50 mg) 3 times per day, along with the meal. The dosage should be gradually adjusted based on the patient’s response to treatment. Check with your doctor.
Iodocasein and thiamine nitrate is a combination of two active ingredients, which are indicated in the treatment of obesity in children and adolescents. Currently, the drug is no longer inu se since 2009 due to the high content of iodine (there have been numerous cases of hyperthyroidism and thyrotoxicosis after prolonged administration of these assets).
Rimonabant (es. Acomplia, Zimulti): the drug is an antagonist of CB1 cannabinoid receptor, located both in the CNS that adipocytes; for this reason, the drug rimonabant is sometimes used in therapy for the treatment of obesity. Take one tablet of medicine a day, before breakfast. It is recommended to follow a low-calorie diet and lifestyle changes correct life.
Amfepramone (es. Diethylpropion): it is recommended that you take this medicine (polysynaptic) at the dosage of 25 mg, three times daily, preferably an hour before a meal and in the early afternoon. Next, I take 75 mg per day, in a single time. In Italy, the drug is currently prohibited.
Phentermine Chloroide (ES. Adipex-P): the drug belongs to the class of amphetamines and is an active slimming (polysynaptic and hunger regulator). The administration of the drug (a 37.5 mg tablet to be taken on an empty stomach before breakfast) should not exceed 21-28 days (the amphetamines addictive and habit-forming); It is recommended to always associate a diet a balanced diet and regular exercise. Is not a first-line drug for the treatment of obesity.
Topiramate is an anticonvulsant, acting drug that is indicated for the treatment of epilepsy and severe headaches (migraines). Because of side effects including weight loss and appetite, is sometimes used in therapy for obesity. It was designed a drug (not entered into Commerce) known as Qnexa, topiramate and formulated with another agent polysynaptic sympathomimetic drug (phentermine). It is not approved for marketing the labelled side effects (suicidal thoughts, lack of memory, palpitations).
And fiber supplements: the administration of these products, pharmaceutical or natural, it is useful to give a perception of fullness stomach who takes them; as a result, the patient feels less stimulation of hunger.
Methylcellulose: Although ideally the methyl cellulose reduces food intake by promoting satiety, actually obese patients who use it do not look satisfactory results. It is most commonly used for the treatment of constipation and for obesity.